Indication and Important Safety Information for Glucagon

Glucagon is a treatment for insulin coma or insulin reaction resulting from severe low blood sugar.

What is the most important information I should know about Glucagon?

  • Glucagon should not be used if you have pheochromocytoma or if you are allergic to Glucagon.
  • Make sure you tell your healthcare provider if you have been diagnosed with or have been suspected of having an insulinoma as Glucagon should be used cautiously in this situation.
  • You and anyone who may need to help you during an emergency should become familiar with how to use Glucagon before an emergency arises. Read the Information for the User provided in the kit.
  • Make sure that your relatives or close friends know that if you become unconscious, medical assistance must always be sought. If you are unconscious, Glucagon can be given while awaiting medical assistance.
  • Do not use the kit after the date stamped on the bottle label.
  • If you have questions concerning the use of this product, consult a doctor, nurse or pharmacist.

WARNING: YOU MAY BE IN A COMA FROM SEVERE HYPERGLYCEMIA (HIGH BLOOD GLUCOSE) RATHER THAN HYPOGLYCEMIA. IN SUCH A CASE, YOU WILL NOT RESPOND TO GLUCAGON AND REQUIRE IMMEDIATE MEDICAL ATTENTION.

Who should not use Glucagon?

Glucagon should not be used if you have pheochromocytoma or if you are allergic to Glucagon.

What should I tell my doctor before taking Glucagon?

Tell your doctor about all of your medical conditions and prescription and over-the-counter drugs. Tell your doctor if you have been diagnosed with or have been suspected of having pheochromocytoma or an insulinoma.

How should I use Glucagon?

  • Act quickly. Prolonged unconsciousness may be harmful.
  • Make sure your family and friends know to turn you on your side to prevent choking if you are unconscious.
  • The contents of the syringe are inactive and must be mixed with the Glucagon in the accompanying bottle immediately before giving injection. Do not prepare Glucagon for Injection until you are ready to use it.
  • Glucagon should not be used unless the solution is clear and of a water-like consistency.
  • The usual adult dose is 1 mg (1 unit). For children weighing less than 44 lbs. (20 kg), give 1/2 adult dose (0.5 mg). For children, withdraw 1/2 of the solution from the bottle (0.5 mg mark on syringe). Discard unused portion.
  • You should eat as soon as you awaken and are able to swallow. Inform a doctor or emergency services immediately.

What is some important Information I should know about Low Blood Sugar (Hypoglycemia)?

  • Early symptoms of low blood sugar include: sweating, drowsiness, dizziness, sleep disturbances, palpitation, anxiety, tremor, blurred vision, hunger, slurred speech, restlessness, depressed mood, tingling in the hands, feet, lips, or tongue, irritability, lightheadedness, abnormal behavior, inability to concentrate, unsteady movement, headache, and personality changes. These symptoms may be different for each person and can happen suddenly.
  • If your low blood sugar is not treated, you may progress to severe low blood sugar that can include: disorientation, seizures, unconsciousness, and death.
  • Low blood sugar symptoms should be treated with a quick source of sugar which should always be carried with you. If you do not improve or you are unable to take a quick source of sugar, you should be treated with Glucagon or with intravenous glucose at a medical facility.

What are the possible side effects of Glucagon?

  • Severe side effects are very rare, although nausea and vomiting may occur occasionally.
  • A few people may be allergic to Glucagon or to one of the inactive ingredients in Glucagon, or may experience rapid heart beat for a short while.
  • If you experience any other reactions which are likely to have been caused by Glucagon, please contact your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

How should I store Glucagon?

  • Before dissolving Glucagon with diluting solution, store the kit at controlled room temperature between 20° to 25°C (68° to 77°F).
  • After dissolving Glucagon with diluting solution, use immediately. Discard any unused portion. Glucagon should be clear and of a water-like consistency at time of use.

Glucagon is available by prescription only.

For more safety information, please see Information for the User and Information for the Physician.

HI GLUC CON ISI 09OCT2014

The Glucagon design is a trademark of Eli Lilly and Company. Glucagon is available by prescription only.

Apple®, the Apple logo, and iPhone® are trademarks of Apple Inc., registered in the US and other countries. App Store is a service mark of Apple, Inc.

Android and Google Play are trademarks of Google Inc.

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What Is Glucagon?

Glucagon is a medicine that’s different from insulin. It’s used to treat severe low blood sugar (hypoglycemia). Glucagon works by telling your body to release sugar into the bloodstream to bring the blood sugar level back up.

Sometimes, if you miss a meal, exercise too much, or don’t eat enough food for the amount of insulin you’ve taken, it can lead to low blood sugar. If not treated quickly, mild or moderate low blood sugar can become severe. In these cases, if you are physically unable to eat or drink a quick source of sugar, you may lose consciousness. When this happens, you’ll need Glucagon.

Giving a Glucagon shot can be scary, but it’s very important to recognize the symptoms of severe low blood sugar and be ready to use Glucagon. Take a moment to become familiar with your Glucagon kit—it’s small and portable and houses all the items needed to administer Glucagon in a bright red case. It’s a good idea to open the case and look at the contents. You and anyone who may need to help you during an emergency should also know how to use Glucagon before an emergency arises. Be sure to read the Information for the User provided in the kit.

An open Glucagon kit revealing its contents
Vial of sterile glucagon Syringe of sterile diluting agent
  • Attached needle
  • Instructions for Use
  • Vial (bottle) of
    sterile Glucagon
  • Syringe of sterile
    diluting agent

Treating Severe Low Blood Sugar

A key to managing an episode of severe low blood sugar (hypoglycemia) is to be prepared. If not treated quickly, mild or moderate low blood sugar can become severe.

Severe low blood sugar is very serious. If it happens, loss of consciousness may occur and you may be physically unable to eat or drink a rapid-acting source of sugar (glucose). You may need a Glucagon shot and a family member, friend, or another adult will need to be ready to give it to you.

Make sure that your relatives and close friends know that if you become unconscious, medical assistance must always be sought. If you are unconscious, Glucagon can be given to you while awaiting medical assistance.

Warning: You may be in a coma from severe hyperglycemia (high blood glucose) rather than hypoglycemia. In such a case, you will not respond to Glucagon and will require immediate medical attention.


Vial of glucagon Syringe

Tips and Tools to Help You Prepare for Severe Low Blood Sugar

Be Prepared With Multiple Kits

Be prepared with multiple kits

Make sure you always have a Glucagon kit with your other diabetes supplies when you’re away from home. It’s important to have more than one kit and consider keeping one at school, at work, with close relatives, and in places where you or your child spend a lot of time. Close friends, co-workers, family members, school nurses, and coaches should know where your kits are and how to use them.

Here’s a handy checklist of some of the most common places to keep Glucagon kits:

For Children

  • in the school nurse’s office
  • at daycare or with the sitter
  • with the coach
  • at homes of relatives

For Adults

  • at the workplace
  • with you when traveling
  • at the homes of close friends
  • in your college dorm room
Glucagon Kit Glucagon Kit Glucagon Kit

*Check with your insurance company to find out how many kits you can get for a single co-pay.

Check Your Kit’s Expiration Date
An example expiration date on the back of a glucagon kit
Small picture of the back of a Glucagon Kit

Check your kit’s expiration date

Severe low blood sugar can happen anytime, which makes it important to plan ahead. Look at your kit’s expiration date each time you get a new prescription. The expiration date can be found on the outside label under “Exp. Date/Control No.” on the outer red case, and also on the bottle. The date will be written as mm yyyy to reflect the month and year of expiration. An expired Glucagon kit should never be used.

  • Check your kit’s expiration date
  • Add your kit’s expiration date to your calendar one month before it expires
  • Ask your doctor for a new prescription

You can also set reminders with the Manage My Kits feature within the FREE Glucagon App.

Download the FREE App

Download the FREE app

The Lilly Glucagon mobile app puts the information you need right in your hands. Ask those close to you to download the app as well so they are better prepared to help if you should ever experience severe low blood sugar.

The FREE Glucagon App lets you:

  • Walk through each step of administering Glucagon using the touch-screen simulator
  • Use Glucagon in an actual emergency with step-by-step guidance, including an audio option that can help you follow the instructions
  • Keep track of the locations of your emergency kits in the kit log and set expiration date reminders

Read the Glucagon brochure

Read the Glucagon brochure

The Glucagon brochure includes important information about severe low blood sugar and treating it with your Glucagon kit. It also includes step-by-step instructions for use and helpful reminder cards to place wherever you keep your Glucagon kits.

How to Use Glucagon

Be sure to designate several people who can help in case of an emergency. In the event of severe low blood sugar (hypoglycemia), you will not be able to inject yourself with Glucagon. It may help you feel more at ease to know that several people such as friends, the school nurse, your coach, and co-workers know where your kits are located and how to use them in case you experience severe low blood sugar. Consider asking others to download the Glucagon App and view this website.

An open Glucagon kit
  1. Step-by-Step
    Instructions

    SWIPE TO VIEW >

  2. Step 1

    Flip off the seal from the vial of Glucagon powder.

  3. Step 2

    Remove the needle cover from the syringe. DO NOT REMOVE THE PLASTIC CLIP FROM THE SYRINGE, as this may allow the push rod to come out of the syringe.

  4. Step 3

    Insert the needle into the rubber stopper on the vial, then inject the entire contents of the syringe into the vial of Glucagon powder.

  5. Step 4

    Remove the syringe from the vial, then gently swirl the vial until the liquid becomes clear. Glucagon should not be used unless the solution is clear and of a water-like consistency.

  6. Step 5

    Insert the same syringe into the vial and slowly withdraw all the liquid. In children weighing less than 44 pounds, withdraw half of the liquid (0.5 mark on the syringe).

  7. Step 6

    Cleanse site on buttock, arm, or thigh and inject Glucagon immediately after mixing, and then withdraw the needle. Apply light pressure against the injection site.

  8. Step 7

    Turn the person on his/her side. When an unconscious person awakens, he/she may vomit.

    Call 911 immediately after administering Glucagon. If the person does not awaken within 15 minutes, you may administer a second dose of Glucagon, if previously instructed by your healthcare provider to do so.

  9. Step 7 (continued)

    As soon as the person is awake and able to swallow, give him/her a fast-acting source of sugar (such as fruit juice), followed by a snack or meal containing both protein and carbohydrates (such as cheese and crackers, or a peanut butter sandwich).

  10. Step 8

    Discard any unused reconstituted Glucagon.

    Remember to notify your healthcare provider that an episode of severe hypoglycemia has occurred.

    These are not the complete instructions. Go to Information for the User for complete instructions on how to administer Glucagon.

Frequently Asked Questions

Some of the answers to the most commonly asked questions about Glucagon and severe low blood sugar are here. Don’t see what you’re looking for? Ask Lilly or call your doctor.

About Glucagon

  • What is it?

    Glucagon is a medicine that is different from insulin and is used to treat severe low blood sugar (hypoglycemia). It works by telling your body to release sugar into the bloodstream to bring the blood sugar level back up. In your Glucagon kit you’ll find a vial of sterile Glucagon, a syringe of sterile fluid with an attached needle, plus the complete Information for the User.

  • Why does it have to be mixed?

    Glucagon must be mixed with the syringe of sterile fluid to dissolve the powder for injection. The solution should be clear and of a water-like consistency at time of use.

  • How does it work?

    Glucagon is a hormone made in the pancreas. Glucagon raises blood sugar by releasing glucose from the liver.

  • Can I use it more than once?

    No, you cannot use the same syringe or kit more than once. Use immediately after mixing and discard any unused portion.

  • Who should administer it?

    Glucagon can be administered by anyone who is comfortable giving the injection. Show your family members and others where you keep your kit and how to use it. They need to know how to use it before you need it. It is important that they practice. They can practice giving a shot by giving you your normal insulin injection. A person who has never given a shot will probably not be able to do it in an emergency.

  • How should Glucagon be stored?

    Before dissolving Glucagon with diluting solution: Store the kit at room temperature (68° to 77°F). Do not refrigerate or freeze. Keep away from direct sunlight. After dissolving Glucagon with diluting solution: Use immediately and discard any unused portion.

  • Does my Glucagon kit expire?

    Yes! The expiration date can be found on the outside label under “Exp. Date/Control No.” on the outer red case. The date will be written as mm yyyy to reflect the month and year of expiration.

  • If it is stored properly, can I use my Glucagon kit past the expiration date?

    No. Glucagon kits should never be used past the expiration date—even when stored properly.

  • Why does the prefilled syringe have a different expiration date?

    Although the expiration date on the outside of the kit may be different than the expiration date on the syringe, it is the outer date (on the back of the red box) you should always reference. The kit (as a whole) expires when the earliest expiration date of any of the items contained in the kit occurs.

  • How do I dispose of expired or used kits?

    Expired or used kits should be placed in a Sharps container. If a designated container is not at hand, place in a sealed, puncture-proof plastic container clearly labeled “contains Sharps.” Keep the container away from children. For further information on Sharps disposal, visit www.fda.gov and search for “Sharps disposal.”

  • Where should kits be kept?

    Keep kits with other diabetes supplies wherever you or your child spends time. For children this may be with the school nurse, at daycare, at camp, and with the coach. Adults will want to have a Glucagon kit at the workplace, at home, at the homes of relatives, and in the dorm room. See Be Prepared With Multiple Kits and ask your doctor about getting a prescription for more than one kit in order to have one at multiple locations.

  • Who should know how to use Glucagon kits?

    It’s important that the people you or your child spends time with know what to do in case of a severe low blood sugar event. This may include family, friends, and coworkers (caregivers). By downloading the free Glucagon app, they can learn more about how to administer Glucagon and be prepared ahead of time.

About Severe Low Blood Sugar (Hypoglycemia)

  • What is severe hypoglycemia?

    Hypoglycemia (low blood sugar) is a condition characterized by abnormally low blood glucose (sugar) levels—usually less than 70 mg/dL.

    Early symptoms of hypoglycemia include:
    • sweating
    • dizziness
    • palpitation
    • tremor
    • hunger
    • restlessness
    • tingling in hands, feet, lips, or tongue
    • lightheadedness
    • inability to concentrate
    • headache
    • drowsiness
    • sleep disturbances
    • anxiety
    • blurred vision
    • slurred speech
    • depressed mood
    • irritability
    • abnormal behavior
    • unsteady movement
    • personality changes

    If not treated, you may progress to severe hypoglycemia. Those symptoms include: disorientation, unconsciousness, seizures, and possible death.

  • Can I prevent severe hypoglycemia?

    Your best bet for preventing severe hypoglycemia is to practice good diabetes management and to learn to detect it at the first signs. Keep simple carbohydrate snacks such as glucose tablets; small, sugary, chewable candies; and juice boxes handy. Sometimes, even though you are diligent about managing your diabetes, severe hypoglycemia happens. That’s when it’s important for you and others around you to know how to use a Glucagon kit, to know where your kits are located, and to have a kit nearby.

  • How does Glucagon help?

    Glucagon is a hormone that stimulates your liver to release stored glucose into your bloodstream when your levels are too low. After injecting Glucagon, an unconscious person will usually awaken within 5-15 minutes and may experience nausea and vomiting. After giving Glucagon, turn the person on his/her side. If vomiting occurs when the person awakens, choking may not occur while in this position. If Glucagon is used, be sure to contact your doctor so that you can discuss ways to prevent hypoglycemia in the future and obtain a new prescription.

Indication and Important Safety Information for Glucagon

Glucagon is a treatment for insulin coma or insulin reaction resulting from severe low blood sugar.

What is the most important information I should know about Glucagon?

  • Glucagon should not be used if you have pheochromocytoma or if you are allergic to Glucagon.
  • Make sure you tell your healthcare provider if you have been diagnosed with or have been suspected of having an insulinoma as Glucagon should be used cautiously in this situation.
  • You and anyone who may need to help you during an emergency should become familiar with how to use Glucagon before an emergency arises. Read the Information for the User provided in the kit.
  • Make sure that your relatives or close friends know that if you become unconscious, medical assistance must always be sought. If you are unconscious, Glucagon can be given while awaiting medical assistance.
  • Do not use the kit after the date stamped on the bottle label.
  • If you have questions concerning the use of this product, consult a doctor, nurse or pharmacist.

WARNING: YOU MAY BE IN A COMA FROM SEVERE HYPERGLYCEMIA (HIGH BLOOD GLUCOSE) RATHER THAN HYPOGLYCEMIA. IN SUCH A CASE, YOU WILL NOT RESPOND TO GLUCAGON AND REQUIRE IMMEDIATE MEDICAL ATTENTION.

Who should not use Glucagon?

Glucagon should not be used if you have pheochromocytoma or if you are allergic to Glucagon.

What should I tell my doctor before taking Glucagon?

Tell your doctor about all of your medical conditions and prescription and over-the-counter drugs. Tell your doctor if you have been diagnosed with or have been suspected of having pheochromocytoma or an insulinoma.

How should I use Glucagon?

  • Act quickly. Prolonged unconsciousness may be harmful.
  • Make sure your family and friends know to turn you on your side to prevent choking if you are unconscious.
  • The contents of the syringe are inactive and must be mixed with the Glucagon in the accompanying bottle immediately before giving injection. Do not prepare Glucagon for Injection until you are ready to use it.
  • Glucagon should not be used unless the solution is clear and of a water-like consistency.
  • The usual adult dose is 1 mg (1 unit). For children weighing less than 44 lbs. (20 kg), give 1/2 adult dose (0.5 mg). For children, withdraw 1/2 of the solution from the bottle (0.5 mg mark on syringe). Discard unused portion.
  • You should eat as soon as you awaken and are able to swallow. Inform a doctor or emergency services immediately.

What is some important Information I should know about Low Blood Sugar (Hypoglycemia)?

  • Early symptoms of low blood sugar include: sweating, drowsiness, dizziness, sleep disturbances, palpitation, anxiety, tremor, blurred vision, hunger, slurred speech, restlessness, depressed mood, tingling in the hands, feet, lips, or tongue, irritability, lightheadedness, abnormal behavior, inability to concentrate, unsteady movement, headache, and personality changes. These symptoms may be different for each person and can happen suddenly.
  • If your low blood sugar is not treated, you may progress to severe low blood sugar that can include: disorientation, seizures, unconsciousness, and death.
  • Low blood sugar symptoms should be treated with a quick source of sugar which should always be carried with you. If you do not improve or you are unable to take a quick source of sugar, you should be treated with Glucagon or with intravenous glucose at a medical facility.

What are the possible side effects of Glucagon?

  • Severe side effects are very rare, although nausea and vomiting may occur occasionally.
  • A few people may be allergic to Glucagon or to one of the inactive ingredients in Glucagon, or may experience rapid heart beat for a short while.
  • If you experience any other reactions which are likely to have been caused by Glucagon, please contact your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

How should I store Glucagon?

  • Before dissolving Glucagon with diluting solution, store the kit at controlled room temperature between 20° to 25°C (68° to 77°F).
  • After dissolving Glucagon with diluting solution, use immediately. Discard any unused portion. Glucagon should be clear and of a water-like consistency at time of use.

Glucagon is available by prescription only.

For more safety information, please see Information for the User and Information for the Physician.

HI GLUC CON ISI 09OCT2014

The Glucagon design is a trademark of Eli Lilly and Company. Glucagon is available by prescription only.

Apple®, the Apple logo, and iPhone® are trademarks of Apple Inc., registered in the US and other countries. App Store is a service mark of Apple, Inc.

Android and Google Play are trademarks of Google Inc.

Indication and Important Safety Information
Glucagon is a treatment for insulin coma or insulin reaction resulting from severe low blood sugar.